What's the smallest geographic slice to browse ACS data?

Hello, new to the forum Wave

I’m exploring data in the ACS 5-year survey data. I thought I’d look at the census tract-level, but notice that in many tables the data has large margins of error, with a coefficient of variation 50% or more (screenshot).

When looking at ACS 5-year data, what’s the smallest geographic slice you look at? Seems like the zip code is where margin of error comes within a tolerable range? Of course would depend on the specific table. Tables that include multi-dimensional demographic slicing probably still have a high MOE at the zip code level.

Thanks,